G6pd Deficiency – How to support Glutathione and Ribose
G6pd (Glucose-6-phosphate dehydrogenase) deficiency is the most common enzyme defect in humans. It effects glucose energy metabolisim and particularly red blood cell metabolism, resulting in hemolytic anemia.
Certain foods are off limits to people with this deficiency, in particular broad beens and other legumes as they contain high levels of certain compounds which cause high levels of oxidative stress in these individuals. Also a number of medications such at antibiotics should be avoided too.
The reason I was looking at the G6pd deficiancy is because someone emailed me asking if a specific supplement would be beneficial so I dug into the science of the problem and did some research.
Reading the wikipedia page on it says:
The G6PD / NADPH pathway is the only source of reduced glutathione in red blood cells (erythrocytes). The role of red cells as oxygen carriers puts them at substantial risk of damage from oxidizing free radicals except for the protective effect of G6PD/NADPH/glutathione.
People with G6PD deficiency are therefore at risk of hemolytic anemia in states of oxidative stress. Oxidative stress can result from infection and from chemical exposure to medication and certain foods. Broad beans, e.g., fava beans, contain high levels of vicine, divicine, convicine and isouramil, all of which are oxidants.
When all remaining reduced glutathione is consumed, enzymes and other proteins (including hemoglobin) are subsequently damaged by the oxidants, leading to electrolyte imbalance, cross-bonding and protein deposition in the red cell membranes
We can see here one main issue complicating issues with the condition is low levels of glutathione, which is the body’s master antioxidant. Low levels of glutathione are implicated is over 74 major diseases.
Your cells create glutathione from three amino acids, and the one in most short supply inside the cells is Cysteine. Also your body required ATP energy to create the glutathione.
And what is ATP created from? One of the main components of ATP is the sugar Ribose. If you look at the pentose phosphate pathway, which G6PD is a part of, it converts glucose to Ribose-5-Phosphate.
Medical researchers have long looked for ways to deliver Cysteine inside the cells intact to create glutathione. N-Acytyl-Cysteine has been used in the past, and while it works it has limited effectiveness by itself.
It took a very smart medicial chemist to come up with a superior solution. After Dr Nagasawa was finished with his work creating the new fast acting cyanide antidote he focused on making his Cysteine compound available for us.
He researched a compound over many years which protected the Cysteine with Ribose, providing an elegant double-whammy.
I’ve been taking the Cellgevity product which contains the RiboCeine compound for a while, and many top doctors and atheletes swear by it.
While healthy people see many benefits, given this look at the science of G6pd deficiency, Cellgevity is worth a serious look by anyone with the condition.
As always consult your doctor before taking any medication or supplements if you have this deficiency.
You will be finding out more about how Cellgevity can make you feel better, in a short time, by clicking here
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- G6PD and protein supplements