New Daily Persistent Headache (NDPH) – Possible cause and treatment?
I become such a wuss when I get a headache, quickly reaching for the neurofen, I can only imagine how people with daily persistent headaches cope. I know a young guy who suffers from it and it must be extremely annoying to deal with that while studying at school and university. What sparked my interest is hearing a guy who lives locally to me telling how he managed to overcome daily migraines, more on that in a sec.
A while ago I was searching through the publish science articles and found one article (http://www.ncbi.nlm.nih.gov/pubmed/17635596) investigating the link between NDPH and Tumor Necrosis Factor Alpha (TNF-a), which is one of the primary inflammatory markers and a proinflammatory cytokine involved in brain immune and inflammatory activities, as well as in pain initiation. They look at the CSF (Cerebral spinal fluid) levels of TNF-a and found it was elevated in people who suffered from chronic daily headaches such as chronic migraine (CM), and post-traumatic headache (PT).
Their conclusion stated:
An elevation of CSF TNF alpha levels was found in almost all NDPH patients and suggest a role for TNF alpha in the pathogenesis of this condition. Surprisingly, all CM and PT patients tested had elevated CSF TNF alpha levels. In most patients with elevated CSF levels, serum TNF alpha levels were normal. All of these syndromes may be manifestations of CNS [centeral nervous system] inflammation. As most of the positive-tested patients showed minimal to no improvement during aggressive inpatient treatment, persistent elevation of CSF TNF alpha levels may be one of the causes of treatment refractory CDH.
TNF alpha is one of the main inflammation markers which can often be the results of oxidative stress and toxicity at a cellular level. The journal article hypothesized from the data that high levels maybe be on of the causes, so reducing TNF-a could be a possible treatment for these conditions. There are perscription TNF-a blocker drugs, which are often used for auto-immune disorders, however the the prices I’ve seen for them in the online shops are $1,000 to $2,000 for a one month’s supply. Not to mention the side effects of supressing the immune system etc.
The guy I heard from recently who was able to beat his chronic daily migraines was taking a special, unique supplement which address oxidative stress and toxicity. In fact there has been a proper double-blind placebo cross-over clinical study performed with the product and it was found the human subjects had on average a 61% decrease in TNF-a after 60 days of taking the product, which is significantly better than any other published data I’ve seen for a non-pharmaceutical. Here’s his story:
The product he, and myself, use is called MaxGXL. What it does is significantly raise glutathione, which is your body’s master antioxidant and a primary detoxifier of every cell in your body. If you’re suffering from this condition, I don’t know if this will help , can we certainly can’t make any claims that it might. But given this anecdotale story, some clinical data and some research published in the Headache journal it’s up to you to connect the dots and decide it if it’s worth trying for yourself (If you’re wondering who else is using this product you can check out the extremely experienced medical advisory board for the company behind the product)
Other people found this searching for:
- New Daily Persistent Headache 2012
- new daily persistent headache