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Posted by on Jul 12, 2012 in Science | 0 comments

A Close Look at S-Acetyl-Glutathione

A Close Look at S-Acetyl-Glutathione

Over the last 30 years the number of published scientific articles talking about has gone from half that of Vitamin C, to now double with over 100,000 references on about gluathione.

Although our knowledge and understanding of glutathione’s critical role in cellular health and function has dramatically increased, our ability to support our glutathione levels hadn’t increase so fast.

Supplementing with reduced glutathione or cysteine has been shown to be ineffective so scientists have been looking at new cysteine and glutathione compounds to try and get it into the cell.

For a long time the best supplement was a form of Cysteine called N-Acetyl-Cysteine.  More recently another contender has appeared on the scene which is S-Acetyl-Glutathione.

Acetyl-Glutathione has a the Acetyl group attached to the important sulfhydryl group on the glutathione molecule, which aims to protect it as it travels through acidic the digestive system.

The other challenge is getting inside the cell walls.  Intravenous glutathione has the problem that whole glutathione can’t easy penetrate the cell wall except for a select few cell types.  Studies indicate that S-Acetyl-Glutathione can cross the cell wall to some extent.

So how does it stack up to the reigning champion of glutathione supplementation, RiboCeine (Ribose-Cysteine)?

I’ll compare it on 3 aspects – science, cost and usage/endorsements


Ribose-Cysteine – 25 studies on over the last 25 years.  Much of that research was funded by the National Institutes of Health and the Veterans Administration. Area covered include urotoxicity, hepatotoxicity, radiation, chemoprotection, renal toxicity, and colitis.  Shown to be 300% more effective at raising liver glutathione levels than N-Acetyl-Cysteine.

S-Acetyl-Glutathione – 3 published articles looking at glutathione levels in regards to herpes, fibroblasts and cancer


Ribose-Cysteine – In the Cellgevity formulation there is 125mg of RiboCeine per serve (2 serves per day) plus 622mg of 12 additional ingredients to support glutathione enzymes, liver function, reduce inflammation and support the immune system.  Cost on the loyalty program is US$65 for a 1 month supply

S-Acetyl-Glutathione – On the Nutricology branded product has 100mg per serve (2 serves per day) and costs US$72.00 for a 1 month supply. (Another available brand on the market is Xymogen)


Ribose-Cysteine – Endorsed by many top doctors such as Dr Don Colbert, author the best-selling of Toxic Relief and over 40 other books.  The company that produces it has attracted an extremely experienced and qualified Medical Advisory Board including the Dean of the School of Pharmacy at The University of Wisconsin and a former member of the Stanford heart transplant team. It’s used by many sporting identities such as Chris Mullin, NBA Hall of Fame player, Greg Norman, the famous golfer and many more who are experiencing exceptional results with the RiboCeine based products.

S-Acetyl-Glutathione – Googling for S Acetyl-Glutathione return a number of shop sites selling the supplement, some chemistry/chemical manufacturer sites, and a few health forums with people talking about it.  There seems to be some good results with it, which you would expect for a compound that can deliver glutathione into the cell.


Ribose-Cysteine (RiboCeine) beats S Acetyl-Glutathione in the extent of it’s research, being better value for money, and having a much higher profile in the medical and sports community.  I don’t see any reason not to take S-Acetyl-Glutathione and it’s good to see researchers creating and researching new avenues of glutathione supplementation, however at the end of the day the Cellgevity formulation containing Ribose-Cysteine is still my preference.  I’ve been taking Cellgevity myself for a few months with good results and have seen exception results with many of the other product users.  Check out some of the testimonials at

It’s only taken 25 years of research but now the unmatched leader in glutathione, your master cell protector, is here.  Grab yourself some Cellgevity here and start enjoying all the benefits of increased glutathione.

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